This course provides the basic biochemical knowledge essential to the student's subsequent medical education experience. In addition, this course is intended to provide insight, where possible, into the mechanisms of disease at the molecular level. Finally, the course gives an adequate foundation to interpret and evaluate the current medical biochemical literature and stimulate continued education beyond the formal experience.

To be determined.

: To carry out research under the supervision of a sponsoring faculty member. The student will help design experiments, learn and apply established techniques, record and evaluate data and make a final report both written and oral that describes the overall experimental results. The faculty member will assist the student in the project. This rotation is highly recommended for the student considering a career in academic medicine. Research areas include the biochemistry and molecular biology of cancer, lung diseases, and RNA viruses.

To carry out research under the supervision of a sponsoring faculty member. The student will help design experiments, learn and apply established techniques, record and evaluate data and make a final report both written and oral that describes the overall experimental results. The faculty member will assist the student in the project. This rotation is highly recommended for the student considering a career in academic medicine. Research areas include the biochemistry and molecular biology of cancer, malaria, lung diseases, lysosomal storage diseases, aging, RNA viruses, and drug design/synthesis.

A basic course in biochemistry with emphasis on the physiochemical properties and intermediary metabolism of proteins, carbohydrates, lipids, and nucleic acids. The regulation and integration of metabolic pathways for energy transfer and biosynthesis of major cellular constituents are presented in detail. Enzymes, vitamins, hormones, biochemical genetics, and nutrition are included in the course material.

Students and faculty participate in a supervised reading of current literature and meet once a week to interact in a discussion of the selected article. The goal of this course is to maintain the student's level of information at a "state of the art" in both methods and theory in the discipline and to develop critical skills in reviewing the literature. Student presentation is required to receive credit.

Students participate in research under the direction of a graduate faculty member. The student may pursue independent research or participate in a literature project. This course should be taken by students who have completed their laboratory rotations, but have not yet submitted a research proposal.

This course provides in-depth tutorial exposure to specific areas in the discipline. Student and/or faculty presentations followed by group discussions (usually in the Socratic mode), examine the subject matter in an area of current interest either to one student or to a group of students. Credit and title are arranged with an individual faculty member.

The techniques used for the physical and chemical characterization of protein are presented and protein structure-function relationships, enzyme kinetics, and enzyme mechanisms are presented to provide a student with the basic knowledge to understand the role of functional proteins in life processes.

The focus of this course is on cellular processes involving DNA repair, replication and translation. Current concepts regarding the organization and structure of chromosomes, genes and the regulation of gene expression will be discussed. Eukaryotic molecular biology is emphasized, however some eukaryotic and prokaryotic processes are compared and contrasted. This course stresses the methods and experimental design used to delineate and understand cellular information transfer and molecular phenomena.

Students and faculty present a research topic for discussion before members of the department. The presentations are usually scheduled on a rotational basis. The student may present research data for critique by the faculty.

Independent research by the student under the sponsorship of the graduate faculty. Students are required to submit a research project description form before enrolling in this course. Progress reports of the work accomplished are required every six months.

Lectures by the faculty stress clinically important aspects of anatomy, utilizing both systemic and regional approaches. Student groups of four dissect the entire human body. Prosections and computer programs are available to augment information learned in the laboratory. The lecture and laboratory material is reinforced through physician- presented correlation conferences. Additionally, the students are required to complete a computer program in radiological anatomy.

The main objective is to teach the miscroscopic structure and functional anatomy of cells, tissues, and organs of the human body through lectures, laboratories, slides, demonstrations, and examinations. The course provides the student the opportunity to gain information and experience in the science of microscopic structure and to learn essential basic terminology for use and expansion in future courses.

Summer make-up course in Medical Histology at an LCME approved medical school.

The course presents a synopsis of human development and related information. Clinically related topics are emphasized while normal development is closely correlated with the systemic lectures given in the gross anatomy course

The course consists of both laboratory and lecture material. Emphasis is given to the functional neurobiology of the human central nervous system. In addition to basic anatomical systems, considerable time is given to the delineation of the anatomical bases of human CNS dysfunction.

This course is an organ-based multi-disciplinary course combining neuroanatomy, neuropathology, and neurophysiology to provide an integrated approach to neuroscience. The final exam is a mini-board from the National Board of Medical Examiners; students are charged a fee to purchase this exam.

To be determined.

Each student is responsible for completing the dissection and study of the anatomy of the upper and lower extremeties and selection and review of recent literature related to the region under study. Time will be divided between laboratory dissection, library reference study, and conference sessions with faculty, both clinical and basic science. Conferences directed by faculty will deal with the basic anatomy, both normal and anomalous, and with the practical utilization of that knowledge. Conferences directed by the student will deal with techniques from current literature.

Each student is responsible for completing the dissection and study of the anatomy of the thorax, abdomen, and pelvis, and selection and review of recent literature related to the region under study. Time will be divided between laboratory dissection, library reference study, and conference sessions with faculty, both clinical and basic science. Conferences directed by faculty will deal with the basic anatomy, both normal and abnormal, and with the practical utilization of that knowledge. Conferences directed by the student will deal with techniques from current literature.

Each student is responsible for completing the dissection and study of the anatomy of the head and neck, and selection and review of recent literature related to the region under study. Time will be divided between laboratory dissection, library reference study, and conference sessions with faculty, both clinical and basic science. Conferences directed by faulty will deal with the basic anatomy, both normal and abnormal, and with the practical utilization of that knowledge. Conferences directed by the student will deal with techniques from current literature.

The course will consist of three phases: (1) a review of the topographic and internal anatomy of the nervous system; (2) discussions by the faculty concerning current research of interest in neuroanatomy; (3) discussions of functional and clinical neuroanatomy and areas of special interest.

Teaching assistantships are available in the following areas: head and neck; thorax and abdomen; pelvis and perineum; or extremities.

Participants will assist the faculty in teaching histology laboratories either pertaining to tissues (4 weeks) or organ systems (4 weeks, or 8 weeks for both). The student will be mentored by one of the listed faculty who will assume responsibility for the final evaluation of the student.

Teaching assistantships are available in the following areas: head and neck; thorax and abdomen; pelvis and perineum or extremities.

A course consisting of lectures and laboratory experience stressing the more important aspects of human morphology using both systemic and regional approaches supplemented by introductory radiological features.

A study of the structure and function of cells, tissues and organs which includes lectures, demonstrations, and individual laboratory study of slides.

This course consists of lectures and laboratories stressing the important aspects of the structures of the central nervous system and emphasizing the functional aspects which relate to human disease.

A course which presents a synopsis of human development and related information. Clinically related topics are emphasized while normal development is closely correlated with the systemic lectures given in the gross anatomy course

Students and faculty participate in a supervised reading of the current literature and meet periodically (usually once a week) to interact in a discussion of the selected article or topic. the goal of this course is to maintain the faculty's and students' level of information at the "state of the art" in both methods and theory in the discipline to develop critical review skills in reviewing the literature. Student presentation is required to receive credit.

Students participate in research under the direction of a graduate faculty member. The student may pursue independent research or participate in a literature project. This course should be taken by students who have completed their laboratory rotations, but have not yet submitted a research proposal.

This course provides in-depth tutorial exposure to specific areas in the discipline. Student and/or faculty presentations followed by group discussion (usually in the Socratic mode), examine the subject matter in an area of current interest either to one student or to a group of students. Credit and title are arranged with an individual faculty member.

A course which requires students to read and evaluate critically the contemporary literature dealing with the cellular and molecular mechanisms of neural function.

This course requires students to read, present, and evaluate critically the modern literature on cytoskeleton and membrane structure, interactions, and function.

This course requires students to read, present, and evaluate critically the modern literature on gene expression and regulation, repair and therapy.

This course examines embryonic development in animal systems The focus is on the protein and molecular interactions that regulate the development of animal embryos. The course consists of lectures and written exams. Students are required to read from an assigned text and from the primary literature.

Students and faculty present a research topic for discussion before members of the department. The presentations are usually scheduled on a rotational basis. The student may present research data for critique by the faculty.

Independent research by the student under the sponsorship of the graduate faculty. Students are required to submit a research project description form before enrolling in this course. Progress reports of the work accomplished are required every six months.

This course provides a comprehensive coverage of molecular and cellular aspects of carcinogenesis as well as clinical issues related to human cancer. This course will specifically cover areas of histology, pathology, epidemiology, genetics, viruses, oncogenes and tumor suppressor genes. Additionally, topics to be covered include cellular and molecular basis of chemotherapy, pharmacology of anticancer drugs, molecular and cellular basis of radiotherapy, and biological therapy of cancer and clinical trial design.

Students and faculty participate in a supervised reading of current literature and meet once a week to interact in a discussion of the selected article. The goal of this course is to maintain the student's level of information at a "state of the art" in both methods and theory in the discipline and to develop critical skills in reviewing the literature.

Students participate in research under the direction of a graduate faculty member. The student may pursue independent research or participate in a literature project.

The course is taught as an introduction to the study of the diseases of man by developing working definitions and classifications of disease on the basis of known causes and effects. After surveying the structural changes characterizing disease, the mechanisms involved in clinical and lab manifestations are analyzed for human diseases.

This course utilizes the primary scientific literature to provide students with in-depth knowledge regarding the development and utilization of mouse models in biomedical research. Students are required to actively participate in class discussions, present scientific papers, and develop a research project that utilizes mouse models.

Students and faculty participate in a supervised reading of the current literature and meet periodically (usually once a week) to interact in a discussion of the selected article or topic. The goal of this course is to maintain the faculty's and students' level of information at a "state of the art" in both methods and theory in the discipline and to develop critical skills in reviewing the literature.

Theoretical and practical training in basic skills utilized in basic medical science research laboratories, for students entering the first year interdisciplinary curriculum. Discussion of regulatory issues in biomedical research will be interwoven with hands-on laboratory exercises. Offered concurrently with IDL 580.

First of a two-semester sequence designed for students in the first year interdisciplinary curriculum. In-depth exploration of the fundamentals of biochemistry, cell biology, and molecular biology prerequisite to advanced study of basic medical sciences. Didactic lectures will be complemented with discussions of the literature.

Second of a two-semester sequence designed for students in the first year interdisciplinary curriculum. Detailed exploration of the fundamentals of microbiology and immunology, developmental biology, integrative systems physiology, and mechanisms of drug action prerequisite to advanced study of basic medical sciences. Didactic lectures will be complemented with discussions of the literature.

In-depth tutorial exposure to interdisciplinary topics in Basic Medical Sciences.

Directed research study under the direction of a member of the graduate faculty.

Directed research study under the direction of a member of the graduate faculty. This course should be taken by students who have not yet identified a major professor in Basic Medical Sciences.

A seminar course in which outside speakers are brought in to discuss their research. Students will attend the seminar and have an opportunity to meet informally with the speaker. Attendance will be required, and the material will be testable during each student's qualifying exam.

Fundamental concepts of medical instrumentation, biomedical imaging and biological systems modeling as used in biomedical engineering. Course is cross-listed with EG 620.

Fundamental concepts of transport phenomena, cellular and tissue mechanics, and materials as used in biomedical engineering. Course is cross-listed with EG 621.

This course introduces an advanced level of lung physiology. An understanding of fundamental lung development, anatomy, and cell and organ physiology is emphasized. The course consists of lectures and written assignments and essay exams. Reading assignments are from the primary literature.

This course builds on an in-depth understanding of normal lung biochemistry, cell biology, pharmacology, and physiology to examine lung disease. Emphasis is given on understanding mechanism(s) underlying the genetic, cell biology, anatomy and physiology of disease development and progression. Current therapeutic interventions are discussed. Clinical correlations are utilized to track signs and symptoms of specified diseases, and provide a framework for treatment options. The course consists of lectures and written assignments and essay exams. Reading assignments are exclusively from the primary literature.

This course builds on signal transduction topics discussed in the Fundamentals course (IDL 580, 581). The mechanisms of more generalized signaling pathways (e.g., G-protein couples pathways) to specific signaling pathways (e.g., TGF/BMP family) will be discussed. Signal transduction pathways will be examined using classic literature references, from the molecular details of pathway components to the effects on the organ-system. The course consists of lectures, student presentations, and essay/problem solving examinations.

This course covers statistical analysis, logic and hypothesis-driven experimental design in biomedical research, utilizing a combination of lectures, weekly practical data sets or written assignments, and student presentation.

This course provides strategies to improve communication skills via construction of logical scientific arguments and effective writing. Course format will include lecture/discussion, in class practical exercises, and writing assignments. In addition, participants will be introduced to the Turnitin software, reference databases, and other electronic resources useful in preparation of proposals and manuscripts.

Students meet on alternate weeks for 2 hr with faculty and other research professionals to discuss on-going research projects in the field of smooth muscle and vascular biology. Signal transduction pathways, pathophysiological mechanisms in vascular disorders associated with smooth muscle, and other topics of interest will be discussed. Emphasis will be on up-to-date research results from laboratories as well as newly published literature findings. Students will be expected to present the results of their own laboratory research at least once a year to the group.

In-depth exposure to selected topics in lung biology or pathobiology. Course may be repeated for credit when course content varies.

Students and faculty present a research topic for discussion before members of the Center for Lung Biology. The presentations are usually scheduled on a rotational basis. The student may present research data for critique by the faculty.

Students and faculty present a research topic for discussion before members of the department. The presentations are usually scheduled on a rotational basis. The student may present research data for critique by the faculty.

Students and faculty participate in a supervised reading of the current literature and meet once a week to discuss the selected article or topic and its relation to ongoing research. The goal of this course is to maintain the faculty's and students' level of information at a "state of the art" in both methods and theory in the discipline and to develop critical skills in reviewing the literature of lung biology.

The course treats the conception, construction, criticism, and deployment of statistical models of biomedical data. Models of dose-response, identification, and survival are developed and applied to lab, clinical and epidemiological data. Course covers linear, generalized linear, and non- linear models of continuous, discrete, and censored data, and includes topics in experimental design, regression diagnostics, salvage of weak parameter estimates, and meta- analysis. Course is organized, for the greater part, on a case-study format.

Independent research by the student under the sponsorship of the graduate faculty in individual departments in the Basic Medical Sciences. Prerequisite: Approved formal research proposal

This course presents the fundamental aspects of pathogenic microbiology including morphology, metabolism and replication of micro-organisms, the basic principles of the use of chemotherapeutic agents, microbial genetics, and medical microbial ecology. The major bacterial, viral, mycotic, and parasitic diseases of humans are covered in detail. The basic principles of immunology and infection in relation to clinical disease of the various body systems are discussed.

To be determined.

Bench research on the biology or the rickettsiales family of intracellular pathogens and on the pathogensis of the diseases caused by these organisms. Participation in ongoing research or inititation of new projects are possible.

Bench research on the biology or the Rickettsiales family of intracellular pathogens and on the pathogenesis of the diseases caused by these organisms. Participation in ongoing research or initiation of new projects are possible.

Presents the fundamental aspects of microbiology including morphology, metabolism of micro-organisms, the basic principles of the use of antibiotics and chemotherapeutic agents, microbial genetics, virology, and medical microbial ecology. The principles of immunology and infection in relation to clinical disease are discussed with special emphasis on laboratory diagnosis.

Students and faculty participate in a supervised reading of the current literature and meet periodically to interact in a discussion of the selected article or topic. The goal of this course is to maintain the faculty's and students' level of information at a "state of the art" in both methods and theory in the discipline and to develop critical skills in reviewing the literature.

Students participate in research under the direction of a graduate faculty member. This course should be taken by students who have completed their lab rotations, but have not yet submitted a formal research proposal.

Each course provides in-depth tutorial exposure to specific areas in the discipline. Student and/or faculty presentations followed by group discussions, examine the subject matter in an area of current interest either to one student or a group of students. Credit and title are arranged with an individual faculty member.

This course discusses the fundamentals of this area with particular emphasis on Escherichia coli and Salmonella typhimurium as model systems. The development of problem solving skills will be stressed. Topics including aerobic vs. anaerobic metabolism, membrane physiology, biosynthesis of macromolecules and regulation of gene expression provide view of microbial cell.

Selected topics in immunology are considered using formal lectures followed by student presentations. Design and interpretation of immunological experiments are emphasized throughout the course.

This course reviews the reproductive cycles of important human viruses and subviral agents and the diseases they cause. The focus is on the molecular biology of animan viruses and their mechanisms of regulation, assembly, and pathogenesis. Human immunodeficiency virus will be considered in detail. The course is constructed as an interactive lecture series with student reports and literature surveys.

Students present a research topic for discussion before members of the department. Usually scheduled on a rotational basis. Student participation required after end of second year. Attendance required.

Independent research by the student under the sponsorship of the graduate faculty in individual departments in the Basic Medical Sciences. Students are required to submit a research project description form before enrolling in this course. Progress reports of the work accomplished are required every six months.

This course is designed to provide the student with a basic understanding of the actions of drugs and their clinical uses. Basic principles, including dose-response relationships and receptor theory, are emphasized. Current concepts of drug effects, mechanisms, and sites of action are explored in detail with respect to major classes of drugs. Important considerations are also given to drug interactions and the toxicology of therapeutic agents, chemicals in the environment, and other biologically active substances.

Students and faculty participate in a supervised reading of the current literature and meet periodically (usually once a week) to interact in a discussion of the selected article or topic. The goal of this course is to maintain the faculty's and students' level of information at a "state of the art" in both methods and theory in the discipline and to develop critical skills in reviewing the literature. Student presentation is required to receive credit.

Students participate in research under the direction of a graduate faculty member. The student may pursue independent research or participate in a literature project. This course should be taken by students who have completed their laboratory rotations, but have not yet submitted a formal research proposal.

This course covers both cellular and organ system physiology It is designed to prepare graduate students for Medical Pharmacology (PHA 540), and for research in pharmacology.

Each course provides in-depth tutorial exposure to specific areas in the discipline. Student and/or faculty presentations followed by group discussions (usually in the Socratic mode), examine the subject matter in an area of current interest either to one student or to a group of students. Credit and title are arranged with an individual faculty member.

This course consists of presentations and literature discussions. The central themes of signal transduction from cellular receptor to amplified response, structure-activity relationships, and drug design are studied comprehensively. Specific topics include receptor-ligand interactions, receptor structure and coupling mechanisms, the biochemical and molecular aspects of G-proteins, protein phosphorylation mechanisms, molecular modeling and protein crystallography. A comprehensive course in biochemistry is prerequisite for this course.

This course is concerned with the mechanisms by which toxic substances exert their effects at the molecular and cellular level. Detailed analysis of the processes by which toxic materials are metabolized to toxic intermediates is addressed. The mode of action of how toxic compounds interact with structural proteins and other macromolecules, enzymes and receptors, and the genome is included. Examples of toxicity of the heart, liver, lung, pancreas, brain, including teratogenic, mutagenic and carcinogenic effects are discussed at the mechanistic level.

Students present a research topic for discussion before members of the department. The presentations are usually on a rotational basis. The student may present research data for critique by the faculty.

Independent research by the student under the sponsorship of the graduate faculty in individual departments in the Basic Medical Sciences. Students are required to submit a research project description form before enrolling in this course. Progress reports of the work accomplished are required every six months.

This course includes lectures and labs which introduce the student to the basic functions of the heart, circulation, lung, and kidney, as well as the endocrine, nervous, and gastrointestinal systems. Fundamental mechanisms are stressed with the intent of providing the student with the basic knowledge of organ function necessary for the understanding and treatment of disease. Overall integrated response of body to various stresses is discussed in detail.

Students and faculty participate in a supervised reading of the current literature and meet periodically to interact in a discussion of selected article or topic. The goal of this course is to maintain the faculty's and students' level of information at a "state of the art" in both methods and theory in the discipline and to develop critical skills in reviewing the literature. Student presentation is required to receive credit.

Students participate in research under the direction of a graduate faculty member. Student may pursue independent research or participate in a literature project. This course should be taken by students who have completed their lab rotations, but have not yet submitted a formal research project.

Each course provides in-depth tutorial exposure to specific areas in the discipline. Student and/or faculty presentations followed by group discussions (usually in the Socratic mode), examine the subject matter in an area of current interest either to one student or to a group of students. Credit and title are arranged with an individual faculty member.

This is an advanced course covering cardiac function and metabolism, peripheral circulation, and microcirculation. The objective is to provide the student with a thorough understanding of cardiovascular physiology at both the organ and cellular level.

This course is designed to present a detailed analysis of physiological membranes and the physical principles governing the movement of solute and water across these barriers.

Students present a research topic for discussion before members of the department. The presentations are usually scheduled on a rotational basis. The student may present research data for critique by the faculty.

Independent research by the student under the sponsorship of the graduate faculty in individual departments in the Basic Medical Sciences. Students are required to submit a research project description form before enrolling in this course. Progress reports of the work accomplished are required every six months.